Carboxytherapy is a mesotherapy like non-surgical procedure used to infuse CO2 gas below the skin (sub-cutaneous or intradermic) through a tiny 30G mesotherapy needle.

    Because CO2 is non-embolic it is very safe if done with the correct protocols and pre treatment medical consultation with a doctor.

    Carbon dioxide is a natural by product of the body and is not toxic even in elevated doses unless a pre existing medical condition exists. There are no known risks associated with carboxytherapy.

    In normal physiology, our cells produce CO2 as a by-product of cellular respiration, the process of breaking down sugars or fats with oxygen.

    After a treatment the gas is totally reabsorbed within 5 minutes and the area treated returns to normal

    Carboxytherapy originated at the Royal Spas of France in 1930 with the treatment of patients afflicted by peripheral arterial occlusive disease. CO2 therapy has been applied to the treatment of stretch marks, cellulite, and hypertrophic scars with impressive results. Studies have demonstrated that carboxytherapy improves skin elasticity, improves circulation, encourages collagen repair, improves the appearance of fine lines and wrinkles, and destroys localized fatty deposits.

    Carboxytherapy is a safe, minimally-invasive Non-surgical procedure that bears minimal risks of side effects.

    Mechanism of action

    The first effects following CO2 injection is a strong vasodilatation, a blood flow increase and a higher pO2 in the treated area.

    The Bohr effect
    Local oxygen release is improved because of the Bohr effect. The Bohr effect describes the tendency of haemoglobin to have less affinity for oxygen when the blood concentration of CO2 is increased. This lower affinity leads the haemoglobin to release the oxygen better in superficial tissues and muscles. CO2 is quickly converted to bicarbonates and H+ acid in presence of the carbonic anhydrase enzyme.

    CO2 + H2O --> H+ + HCO3-

    This reaction causes the tissue’s pH to become acidic with even more dissociation of O2 from haemoglobin, allowing the tissue to become even more oxygenated.

    Stimulation of collagen synthesis

    A 2008 Brazilian study showed a reorganization of collagen fibers following intradermal injections of carbon dioxide and demonstrated that the CO2 is capable of increasing the collagen turnover: a trauma to the dermis launches a healing process with collagen synthesis. CO2 improves the process by first, increasing neovascularization with more healing substances and factors to be on site. In second, it releases more oxygen around and in the healing area, improving the recovery phase.

    Neo-angiogenesis effect

    The first experiments in the 1930s consisted of injecting CO2 into the leg of a frog. They have shown a strong vasodilatation, associated with the creation of new capillaries.

    Receptor activation and lipolysis cascading improvement

    The pressure receptors are stimulated by CO2 injections. Cascading reactions improve the lipolysis process in the injected areas. CO2 is improving the natural lipolysis capabilities of the body.


    • CO2 is a non-toxic & non-embolic gas.
    • It doesn’t increase blood pressure
    • It doesn’t increase CO2 in blood.
    • It doesn’t produce free radicals
    • There isn’t any risk to produce allergy
    • It doesn’t damage connective tissue and we can use it in all areas of the body
    • There isn't any local or general risk
    • It's eliminated by lungs, kidneys and skin

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